Jackson, Sydney N. and Pongdee, Rongson (2019) Progress toward the Synthesis of Pochonin J. International Journal of Organic Chemistry, 09 (02). pp. 96-105. ISSN 2161-4687
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Official URL: https://doi.org/10.4236/ijoc.2019.92009
Abstract
The construction of the C(1) - C(5) fragment of the resorcylic acid lactone pochonin J is described. The synthesis is marked by the installation of the cis-1,3-diol moiety in a highly stereoselective manner using Evans’ intra-molecular base-catalyzed oxyconjugate addition of a hemiacetal-derived nucleophile. The synthetic route presented affords an efficient pathway to the preparation of this critical architectural feature that should facilitate the development of this secondary metabolite as a potential drug candidate.
Item Type: | Article |
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Subjects: | European Scholar > Chemical Science |
Depositing User: | Managing Editor |
Date Deposited: | 11 Feb 2023 05:34 |
Last Modified: | 02 Jan 2024 12:54 |
URI: | http://article.publish4promo.com/id/eprint/601 |