Malignant Post-Transplant Lymphoproliferative Disorder of Nasopharynx in Myelodysplastic Disorder

Luan, Chih-Wei and Chen, Chih-Cheng and Lee, Kam-Fai and Tsai, Ming-Shao and Tsai, Yao-Te and Hsu, Cheng-Ming and Chang, Geng-He (2021) Malignant Post-Transplant Lymphoproliferative Disorder of Nasopharynx in Myelodysplastic Disorder. Healthcare, 9 (2). p. 217. ISSN 2227-9032

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Abstract

(1) Background: Post-transplant lymphoproliferative disorder (PTLD) is a hematological disease and occurs because of immunosuppression after organ transplantation. Only a few studies have reported PTLD in the nasopharynx. In most cases, PTLD developed after solid organ transplantation, and cases of PTLD after bone marrow transplantation, are uncommon. (2) Case presentation: We report the case of a 40-year-old woman with myelodysplastic disorder who underwent hematopoietic stem cell transplantation (HSCT). After 3 months, she developed low-grade fever, progressive nasal obstruction, and bloody rhinorrhea. Endoscopy revealed a mass completely occupying the nasopharynx. A polymorphic PTLD was diagnosed on the basis of histopathological examination results. Reduction in immunosuppression and low-dose radiotherapy were prescribed for treatment. After a 3-year follow-up, no recurrence of PTLD or myelodysplastic disorder was detected. (3) Conclusions: While nasopharyngeal PTLD is rare, a routine examination of the nasopharynx should be considered in the post-transplant follow-up of patients for early detection and treatment of PTLD.

Item Type: Article
Subjects: European Scholar > Medical Science
Depositing User: Managing Editor
Date Deposited: 29 Dec 2022 06:36
Last Modified: 12 Jul 2024 09:31
URI: http://article.publish4promo.com/id/eprint/556

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