Investigating the Topical Anti-inflammatory Activity of Calea prunifolia HBK (Asteraceae) in the TPA Model of Mouse Ear Inflammation

Phytochemical study of Calea prunifolia HBK identified two compounds derived from phydroxyacetophenone,
the compound 1 showed a satisfactory antiinflammatory
activity (58.33%),
when considering that this is a natural product. Although they are structurally similar to antiinflammatory
activity of compound 2 was not significant (2.08%). The test was conducted in a model
of inflammation induced by topical application of 12O-
tetradecanoylphorbol13acetate
(TPA) in the
ear of mice, the positive control was tested with indomethacin and negative controls treated only with
vehicle were tested. These results allow the identification of a pharmacophore group that through
molecular modeling studies and organic synthesis can result in compounds with improved antiinflammatory
activity. Assuming that the difference between the molecules is minimal. It indicates that
the compounds isolated from Calea prunifolia HBK are likely to be modified synthetically to enhance
antiinflammatory
activity with the aim of achieving an active and safe compound.