Prevalence of Urinary Tract Infection and Antibiotic Resistance Pattern in Pregnant Women, Najran Region, Saudi Arabia

Urinary Tract Infection (UTI) is one of the commonest infectious disease in pregnancy, and in
pregnancy we have very limited number of antibiotics to treat the UTI. This study was conducted on
151 patients who attended the gynecology clinic during the study period. Nineteen UTI proven cases
of UTI were studied for prevalence of microorganism and sensitivity pattern against different
antibiotics. Among the bacteria isolated, Escherichia coli (73.68%) and Staphylococcus aureus
(10.52%) were the most prevalent Gram negative and Gram positive bacteria respectively. To know
the resistance pattern of microorganism we used commercially available discs of different antibiotics.
Gram negative bacteria showed more resistance as compared to Gram positive one. It is observed
that the most effective antibiotic for Gram negative isolates is Ceftriaxone (87.5%), followed by
Amoxicillin + Clavulanic acid (81.25%), Amikacin (75%), Cefuroxime (75%), Cefixime (68.75%) and
Mezlocillin (62.5%). For the Gram positive bacteria, Ceftriaxone, Amikacin and Amoxicillin +
Clavulanic acid were the most effective antimicrobials (100%). Multidrug resistance Gram negative
bacteria were also tested for Extended-spectrum Beta Lactamase (ESBL), 35.71% of E. coli isolates
were ESBL producer.