Sialic Acid and Type-2 Diabetes Mellitus

Background: Diabetes mellitus is one of the most common metabolic illnesses characterised by chronic hyperglycemia and is linked to a higher risk of microvascular complications. Serum sialic acid has been identified as a possible risk factor for Type 2 diabetes. Serum sialic acid levels in Type-2 diabetics are frequently higher than in non-diabetic individuals.

Objectives: The objective of the study was to estimate the serum sialic acid in patients with Type 2 Diabetes Mellitus and non-diabetic individuals in NCR, Delhi and evaluating the levels of serum sialic acid with fasting blood glucose in patients with Type 2 Diabetes Mellitus and also in non-diabetic individuals.

Materials and Methods: The study, which took place in Delhi's NCR, was a cross-sectional investigation of 70 people aged 30 to 70. There were two groups of thirty-five people with type-2 diabetes mellitus (15 men and 20 females) and thirty-five people without diabetes who served as controls (16 males and 19 females).

In both groups, fasting blood glucose and serum sialic acid were determined.

Results: Serum sialic acid levels were found to be higher in type 2 diabetes mellitus (76.60±7.89) compared to non-diabetics (39.66±9.55) with a statistically significant p-value of <0.001.

Conclusion: According to the findings of this study, serum sialic levels were found to be higher in Type 2 diabetes patients in Delhi-NCR, indicating that these patients were at risk of developing microvascular problems. As a result, determining sialic acid levels may aid in the early detection and prevention of microvascular problems associated with type 2 diabetes.