Significance of Intralesional Vitamin D3 in Cutaneous Wart

The purpose of this study is to assess the effectiveness and safety of intralesional vitamin D3 in warts. The study comprised 88 patients with recalcitrant warts of various sizes and duration. Vitamin D3 solution (600,000 IU, 15 mg/mL) was injected into the wart's base in amounts ranging from 0.2 to 0.5 mL. A maximum of 5 warts were injected per session at 3-week intervals until resolution or for a maximum of 4 treatments. In order to find any recurrence, patients were monitored for six months after the last injection. Topical Vitamin D has been successfully used for the treatment of warts in some cases. 88 patients completed the study. Complete response was seen in 54 of 60 (90%), partial response in 4 of 60 (6.66%), and no response in 2 of 60 (3.33%). The average number of injections required to achieve a complete resolution was 3.66. Complete resolution of distant warts was noticed in all patients. Recalcitrant warts can be treated effectively, cheaply, and safely with intralesional vitamin D3.