Synthesis and Biological Activity Studies of 7-Benzylideneamino-5H-thiochromeno [2,3-b] pyridin-5-one

The present study reveals the Synthesis of Biologically Active 7-Benzylideneamino-5H-thiochromeno[2,3-b]pyridin-5-one. by Microwave-assisted method. .The present studies on bioactive scaffolds has gained much attention in the field of organic chemistry. Various benzylideneamino-5H-thiochromeno[2,3-b]pyridin-5-one derivatives were synthesized by using microwave irradiation as well as conventional heating method by the reaction of 7-amino-5H-benzothiopyrano[2,3-b]pyridin-5-one with different aldehydes. The compounds were investigated using mass, 1H NMR, IR spectra, and elemental analyses. The antibacterial and antioxidant properties of the Schiff's bases were investigated. Microwave-assisted bioactive heterocycles synthesis provides multi-component synthetic access to a large number of organic molecules having anti-cancer, anti-fungal, anti-bacterial and other bio-activities. The microwave irradiation, ligand, catalyst, substrate and reaction conditions were used to regulate the formation of numerous aza, oxa, and mixed heterocycles with different ring sizes and acyclic system with good yields, demonstrating the elegance, impact and practicality of this microwave assisted technique.