Comparison of the Effect of Vit E, VitB6, Calcium and Omega-3 on the Treatment of Premenstrual Syndrome: A Clinical Randomized Trial

Aims: The purpose of this study is to compare the effect of Vit E, B6, omega-3 and calcium on the treatment of this syndrome.
Study Design: A double blind clinical randomized trial study.
Place and Duration of Study: Department of midwifery, of Islamic Azad University, sari, branch Iran. Between March 2012 and October 2012.
Methodology: Two hundred girls with moderate and severe form of premenstrual syndrome were selected randomly and were divided into five groups. Group 1 received 1g of calcium during 7 final days of the cycle for three cycles. Group 2 received 100 mg of Vit E daily for three cycles. Group 3 received 1g of capsule of fish oil for three months. Group 4 received 40 mg of Vit B6 daily for three months. And group 5 received daily one tablet of placebo for three months and also filled Rosignol Bonlender check list during the use of the drugs. Data were analyzed by SPSS software, and severities of symptoms were compared before and after the intervention in each group and after the treatment in all five groups.
Result: Severity of physical, mental and physical and mental symptoms in patients who received Vit E, VitB6, calcium, omega-3 and placebo reduced (p< 0.05)
Conclusion: It E, Vit B6, calcium, and omega-3 are effective on PMS.