Antioxidant Properties of Plant-Derived Phenolic Compounds and Their Effect on Skin Fibroblast Cells

Merecz-Sadowska, Anna and Sitarek, Przemysław and Kucharska, Ewa and Kowalczyk, Tomasz and Zajdel, Karolina and Cegliński, Tomasz and Zajdel, Radosław (2021) Antioxidant Properties of Plant-Derived Phenolic Compounds and Their Effect on Skin Fibroblast Cells. Antioxidants, 10 (5). p. 726. ISSN 2076-3921

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Abstract

Plants are rich sources of a diverse range of chemicals, many of which have significant metabolic activity. One large group of secondary compounds are the phenolics, which act as inter alia potent reactive oxygen scavengers in cells, including fibroblasts. These common dermis residue cells play a crucial role in the production of extracellular matrix components, such as collagen, and maintaining the integrity of connective tissue. Chronic wounds or skin exposure to UV-irradiation disrupt fibroblast function by the generation of reactive oxygen species, which may damage cell components and modify various signaling pathways. The resulting imbalance may be reversed by the antioxidant activity of plant-derived phenolic compounds. This paper reviews the current state of knowledge on the impact of phenolics on fibroblast functionality under oxidative stress conditions. It examines a range of compounds in extracts from various species, as well as single specific plant-derived compounds. Phenolics are a good candidate for eliminating the causes of skin damage including wounds and aging and acting as skin care agents.

Item Type: Article
Subjects: European Scholar > Agricultural and Food Science
Depositing User: Managing Editor
Date Deposited: 07 Oct 2023 09:32
Last Modified: 07 Oct 2023 09:32
URI: http://article.publish4promo.com/id/eprint/2125

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