Study of Hepatoprotective Effect Produced by the Fruits of Phyllanthus emblicus and Silymarin against Cisplatin Induced Hepatotoxicity

Cisplatin is a cytotoxic drug which induced the hepatotoxicity in the albino mice when intra-peritoneally administered at the dose of 10 mg/kg. Administration of cisplatin raised the level of LFT’s enzymes and also reduced the level of antioxidant enzymes in the liver of the mice. Administration of Phyllanthus emblica extract and silymarin remarkably showed the hepatoprotective effect in the rat. Administration of P. emblica and silymarin decreased the level of ALT, AST, and ALP along with increasing the level of Total protein content. It also increased the level of antioxidant enzymes in the liver of rat showing its hepatoprotective activity.