Lichen Planus Induced by Stevens Johnson Syndrome

The present study reports the appearance of lichen lesions with genital and nail involvement 2 months after the onset of a Stevens-Johnson syndrome (SJS) associated with lamotrigine use. A chronic inflammatory disorder called lichen planus (LP) most frequently affects middle-aged adults. LP can affect the skin or mucous membranes, such as the conjunctiva, vulvovaginal, esophageal, and laryngeal mucosa. A 23-year-old patient was hospitalized in dermatology for SJS that occurred 9 days after taking lamotrigine for treatment of severe depression. The occurrence of cutaneous lichen lesions on the site of a healed dermatosis has been widely reported under the name of Wolf's isotopic response. This isotopic response refers to the appearance of a new dermatosis on the site of an old healed dermatosis.