High Expression of SOD2 Protein Is a Strong Prognostic Factor for Stage IIIB Squamous Cell Cervical Carcinoma

Talarico, Maria Cecília Ramiro and Nunes, Rafaella Almeida Lima and Silva, Gabriela Ávila Fernandes and Costa, Larissa Bastos Eloy da and Cardoso, Marcella Regina and Esteves, Sérgio Carlos Barros and Zanatta Sarian, Luis Otávio and Zeferino, Luiz Carlos and Termini, Lara (2021) High Expression of SOD2 Protein Is a Strong Prognostic Factor for Stage IIIB Squamous Cell Cervical Carcinoma. Antioxidants, 10 (5). p. 724. ISSN 2076-3921

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Abstract

High superoxide dismutase 2 (SOD2) expression is associated with a poor prognosis at many cancer sites, the presence of metastases, and more advanced cervical cancer. This study aims to determine whether SOD2 protein expression is associated with the prognosis of stage IIIB cervical carcinoma. Methods: sixty-three patients with stage IIIB squamous cell cervical carcinoma were included. The evaluation of SOD2 expression by immunohistochemistry was based on a positive cell ratio score and the staining intensity score. Taking disease recurrence and death as endpoints, receiver operating characteristic curves were used to discriminate between high and low SOD2 expression. Results: high SOD2 expression was associated with recurrence (p = 0.001), distant recurrence (p = 0.002), and death (p = 0.005). A multivariate analysis showed that patients with high SOD2 expression had a threefold increased risk for recurrence (HR = 3.16; 1.33–7.51) and death (HR = 2.98; 1.20–7.40) compared with patients who had low SOD2 expression. Patients with high SOD2 expression had shorter disease-free survival (p = 0.001) and overall survival (p = 0.003) than patients with low SOD2 expression. Conclusion: high SOD2 expression is a strong prognostic factor for stage IIIB squamous cell carcinoma of the cervix and could be used as a prognostic marker in women with cervical carcinoma.

Item Type: Article
Subjects: European Scholar > Agricultural and Food Science
Depositing User: Managing Editor
Date Deposited: 13 Jul 2023 03:58
Last Modified: 10 Oct 2023 05:30
URI: http://article.publish4promo.com/id/eprint/2127

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