Diagnosis of Sero-negative Rheumatoid Arthritis Depending on Pathology Associated with Clinical Picture

Objectives: This study was done to assess the role of synovial tissue analysis in rheumatoid arthritis (RA) patients.

Methods: All data were recorded at baseline. All patients underwent clinical, radiologic, serologic, and histological assessments before treatment. Patients were divided into anti-citrullinated protein antibody (anti-CCP) positive and anti-CCP-negative and were compared according to different disease aspects. Correlations between clinical, laboratory, imaging, histological, and pathophysiological data were done for all patients.

Results: There were no statistically significant differences in synovial cell infiltrates according to the serology.

Conclusion: Both study groups had similar synovial cell infiltrates.